For the first time in three decades, researchers think they have identified a new class of antibiotics.
Teams from McMaster University in Ontario, Canada and the University of Illinois, Chicago – led by researcher Gerry Wright – have collaborated in the discovery of Lariocidin, which turned out to be effective against drug -resistant bacteria.
The results were published this week in the journal Nature.
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Lariocidine is a lasso peptide, a chain of amino acids in the shape of Lasso which attacks the bacteria and prevents it from growing and surviving, according to a press release from McMaster.
For the first time in three decades, researchers think they have identified a new class of antibiotics (not illustrated). (istock)
It is produced by a type of bacteria called paenibacillus, which the researchers recovered from a sample of local soil and cultivated in a laboratory for a year.
Paenibacillus has proven to be produced a new substance that attacks antibiotic resistant bacteria.
“Larriocidin is not sensitive to many mechanisms that make bacteria that reside with available antibiotic diseases,” researchers told Fox News Digital.
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The molecule has a unique structure of a “tied lasso or a Bretzel”.
“Lariocidin links to the molecular machine, ribosome, which makes all cell proteins, which is one of the most vital processes of cells,” said researchers.
The observation is important in the light of the growth of antimicrobial resistance, which the World Health Organization has described as a global public health threat. (istock)
“It links to a specific site of the ribosome to which none of the known antibiotics binds and prevents the ribosome from making proteins.”
Another key advantage of lariocidine is that it is not toxic to human cells, the researchers noted.
The observation is important in the light of the growth of antimicrobial resistance, which the World Health Organization has described as a global public health threat which kills more than 4.5 million people worldwide each year.
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“The antibiotic resistance crisis that we are currently faced with a major threat to the way we practice medicine,” researchers told Fox News Digital.
“We must prevent and treat infections if we want to continue to have unhindered access to surgeries, hip expanses, cancer chemotherapy, treatment of premature infants, etc. – therefore, we need new antibiotic drugs to do so in the long term.”
“The antibiotic resistance crisis that we are currently faced with a major threat to the way we practice medicine.”
Dr. Marc Siegel, professor of medicine in the clinic at Nyu Langone Health and Fox News, main medical analyst, applauded the discovery.
“Artificial intelligence promises to improve new drug targets, including antibiotics-and in the meantime, research at McMaster in Canada has found a new class of antibiotics,” he told Fox News Digital.
Dr. Marc Siegel has reiterated that a new class of antibiotics has not emerged for decades – “in part because they are not so profitable, because you do not need it only when they are sick.” (Istock / Fox News)
“This new type of antibiotic – Lariocidine – works by interfering with the synthesis of proteins that many bacteria need to survive.”
Siegel reiterated that a new class of antibiotics has not emerged for decades – “in part because they are not so profitable, because you need it as they are sick.”
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Dr. Stephen Vogel, a family medicine doctor at Plushcare, a virtual health platform with primary care, therapy and weight management options, said this discovery represents a “promising response” to combat infections caused by drug-resistant bacteria.
“Because this microbe can kill bacteria in a way that it cannot evolve to escape, due to its protein production system called the ribosome, it has the potential to be a lasting and durable choice for a wide variety of fatal bacterial infections,” said the doctor based in North Carolina.
“The garden floor may seem commonplace, but it is in fact its own universe of microbes, fungi and bacteria, which can lead to key innovations like the promise that this discovery brings,” said an expert. (istock)
If this microbe was put on the market as an antibiotic, it would mean millions of deaths every year in fewer bacterial infections, according to Vogel.
“The garden floor may seem commonplace, but it is in fact its own universe of microbes, fungi and bacteria, which can lead to key innovations like the promise that this discovery brings,” he added.
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For the future, McMaster researchers will study the means to modify and produce the newly discovered molecule for clinical use, a process that will require a lot of time and resources.
“This discovery is only the starting point for a long development process for this drug molecule,” the researchers told Fox News Digital. (istock)
“This discovery is only the starting point for a long development process for this drug molecule,” the researchers told Fox News Digital.
“What we have to do next is to test if the Lariocidine, which can cure animals, is effective for the treatment of a variety of infections in humans.”
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The researchers added that science is sometimes “fortuitous”.
“You often have to shovel a lot of dirt before finding a jewel, which Lariocidine is certainly. Consequently, the financing of the” shovel shovel “is essential to find new gems.”
